Prolotherapy + Prolozone® Joint Injections | Lococo Wellness Clinic
Lococo Wellness Clinic • Joint Injections

Prolotherapy + Prolozone® Joint Injections

One combined treatment. We always use prolotherapy (dextrose) and Prolozone® (medical ozone) together. Depending on your joint and assessment findings, injections may be placed around the joint, inside the joint, or both.

How It Works

Educational information. Plans are individualized and based on assessment.

Prolotherapy Hamilton • Prolozone Hamilton • Ozone joint injections • Knee OA injections • Frozen shoulder injections

What Is This Treatment?

This service combines two injection components in the same visit: dextrose (medical sugar) and medical ozone (a form of oxygen). We combine them because joint pain often involves both the supporting tissues around a joint and the joint space itself.

Where the injections can go

  • Around the joint (supporting tissues like ligaments, the joint capsule, and tendon attachments)
  • Inside the joint (the joint space)
  • Or a combination of both

What People Often Want Help With

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Less Pain*

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Less Stiffness*

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Better Movement*

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More Stability*

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Better Activity Tolerance*

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Support for Wear-and-Tear Joints*

*Goals vary by person and joint. Timing and degree of change varies.

What We Inject

Dextrose (Prolotherapy)

Dextrose is a medical sugar solution. In simple terms, it helps “wake up” the area and encourages the body to focus on repair and strengthening where it’s needed.

Medical Ozone (Prolozone®)

Medical ozone is a carefully prepared form of oxygen. It helps create a healthier environment for healing by improving oxygen use and calming ongoing joint irritation.

How Each Part Helps (Plain Language)

Dextrose helps with support

  • Supports ligaments and connective tissue
  • Helps improve joint stability
  • Helps joints handle movement and activity better over time

Ozone helps with the healing environment

  • Helps reduce stiffness and irritation
  • Supports healing in tendons, ligaments, and joint tissues
  • Helps improve comfort and ease of movement

Ozone does not replace cartilage or connective tissue, but it can support the body’s natural healing processes.

Joints and Conditions Studied in Research

Clinical research on prolotherapy and ozone-based injections has shown improvements most commonly in pain, stiffness, and function. Individual results vary.

Most Studied

  • Knee: osteoarthritis, degenerative joint changes

Other Joints Studied

  • Shoulder: frozen shoulder; rotator cuff-related pain
  • Hip: osteoarthritis
  • TMJ: joint disorders, including TMJ osteoarthritis
  • Hand/Thumb: thumb CMC osteoarthritis

Peri-Articular / Soft Tissue

  • Ligament-related joint instability
  • Tendon/enthesis-related pain near joints
  • Chronic joint-related musculoskeletal pain

Pre- and Post-Treatment Instructions

Pre-Treatment
  • Eat and hydrate normally unless you are instructed otherwise.
  • Let us know if you take blood thinners or have a bleeding disorder.
  • Tell us if you have an active infection, fever, or new illness symptoms.
  • Tell us if you are pregnant or may be pregnant.
  • Wear comfortable clothing that allows access to the joint being treated.
Aftercare
  • Temporary soreness, stiffness, or swelling can happen after treatment.
  • Gentle movement is encouraged; avoid heavy or high-impact activity at first.
  • Do not “test” the joint immediately after the injection.
  • Follow any rehab or movement guidance provided by your clinician.
  • Contact the clinic if you develop fever, increasing redness/warmth, drainage, or worsening symptoms.

Provider & Delegation

Prolotherapy and Prolozone® injections are administered by Naturopathic Doctors (NDs) under medical directive and delegation from a Nurse Practitioner (NP), where clinically appropriate.

Research References

References are provided for those who wish to review the literature.

Show References
  • Rabago D, et al. Dextrose prolotherapy for knee osteoarthritis: randomized controlled trial. Annals of Family Medicine.
  • Sit RWS, et al. Dextrose prolotherapy for knee osteoarthritis: systematic review and meta-analysis. Scientific Reports.
  • Lopes de Jesus CCL, et al. Intra-articular ozone versus placebo in knee osteoarthritis. PLOS ONE.
  • Systematic reviews/meta-analyses evaluating ozone injections for knee osteoarthritis outcomes.
  • Randomized trials evaluating ozone injections for adhesive capsulitis (frozen shoulder).
  • Clinical studies evaluating ozone injections for hip osteoarthritis outcomes.
  • Clinical trials evaluating ozone injections for TMJ osteoarthritis and TMJ disorders.
  • Registered/ongoing trials evaluating ozone injections for thumb CMC osteoarthritis.

References may include randomized trials, systematic reviews, and registered clinical trials. Ask our team if you would like specific citations.

Ready to Get Started?

We’ll review your joint history, symptoms, and goals and outline a plan for care. If you are an existing patient please book a 30 minute consult with Dr. Lococo, ND to discuss your treatment. If you are a new patient an initial consultation with Dr. Lococo, ND is required.

📍 Schedule Your Appointment

This page is educational and is not a guarantee of outcome. Individual experiences vary.

© Lococo Wellness Clinic — Hamilton, Ontario