NAD⁺ “Longevity IV” | Lococo Wellness Clinic
Lococo Wellness Clinic • IV Therapy
NAD⁺ “Longevity IV”
As we age, our cells naturally make less NAD⁺—the co‑enzyme that fuels sirtuins, your body’s cellular “maintenance crew.” When NAD⁺ is plentiful, this crew helps repair everyday DNA wear‑and‑tear, keeps mitochondria efficient, and coordinates healthy stress responses. Our three‑part protocol is designed to refuel that crew: Step 1 multi‑nutrient IV (Vitamin C, B‑vitamins, amino acids) → Step 2 slow, supervised NAD⁺ infusion → Step 3 glutathione finish.
Why NAD⁺ Becomes Depleted
Over time, lifestyle factors and natural aging processes can drain your body’s NAD⁺ reserves. These are some of the most common contributors to NAD⁺ decline:
- Chronic psychological stress
- Sleep deprivation and circadian disruption
- Excessive alcohol consumption
- High sugar or ultra‑processed diets
- Environmental toxin exposure (pollution, pesticides)
- Inflammation and chronic illness
- Overtraining or repeated intense exertion
- Long‑term medication use
- UV radiation and oxidative stress
- Age‑related metabolic slowdown
These factors increase demand on your cellular repair systems, consuming more NAD⁺ and accelerating its decline.
Session Overview
Each NAD⁺ “Longevity IV” session lasts approximately 2.5–4 hours, depending on your individualized dose and infusion rate. We gradually titrate the dose across visits to allow your body to adapt and to minimize oxidative stress.
Administering NAD⁺ too quickly or without appropriate nutrient cofactors can place extra metabolic demand on mitochondria—potentially generating more oxidative by‑products than your system can neutralize. Our 3‑part protocol is designed to avoid this: the initial multi‑nutrient infusion primes antioxidant systems and energy pathways, the slow NAD⁺ administration maintains balance, and the final glutathione step helps clear reactive oxygen species.
Three‑Part Administration
Step 1: Multi‑Nutrient IV
Vitamin C, B‑complex, and amino acids prepare the body for NAD⁺ metabolism and improve comfort during infusion.
Step 2: NAD⁺ IV
Slow, titrated infusion (≈2–4 hours) with continuous monitoring. Dose increases gradually across sessions for optimal tolerance.
Step 3: Glutathione
Post‑NAD antioxidant support to restore redox balance and assist recovery.
Why Our Protocol Matters
Without nutrient support or with rapid delivery, NAD⁺ can increase oxidative stress and overwhelm detox systems. Our method ensures each step complements the next, promoting balanced cellular rejuvenation and longevity‑focused goals rather than temporary overstimulation.
Eligibility & Safety
Service is offered after clinical review. New patients begin with an initial consultation to individualize the approach.
Recent lab work (within 6 weeks)
- G6PD, CBC
- Vitamin B12, Vitamin D, Ferritin, Iron Panel
- Zinc, Calcium, Magnesium, Chloride, Potassium
- Lipid Panel, Homocysteine
- Amylase, Lipase, hs‑CRP, Creatine Kinase
- eGFR (kidney function)
- TSH, Free T3, Free T4
Who may not be eligible?
- Active infection, uncontrolled illness, or unstable vitals at the visit.
- Allergy or known intolerance to any component in the infusion.
- Pregnancy or lactation unless specifically reviewed and approved by your clinician.
- Other contraindications based on your consultation findings.
Benefits People Often Notice
Every individual’s response is unique, but these are common experiences patients describe after completing the NAD⁺ protocol.
FAQs
Do I need to be an existing patient?
New patients are welcome. An initial consultation is required prior to any IV to ensure NAD⁺ is appropriate for you and to review safety considerations.
How long is the NAD⁺ infusion?
Infusion duration varies by individual and dose. NAD⁺ is typically infused slowly and may be adjusted during the visit based on comfort and monitoring.
Can I book just the NAD⁺ portion?
Our “Longevity IV” is delivered as a three‑step sequence (multi‑nutrient → NAD⁺ → glutathione). Your clinician can discuss options during your consultation.
References
- Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends in Cell Biology. 2014.
- Yoshino J, Baur JA, Imai S‑I. NAD+ intermediates: The biology and therapeutic potential of NMN and NR. Cell Metabolism. 2018.
- Rajman L, Chwalek K, Sinclair DA. Therapeutic potential of NAD+ boosting and sirtuin activation. Cell Metabolism. 2018.
- Katsyuba E, Auwerx J. Modulating NAD+ metabolism, from bench to bedside. EMBO J. 2017.
- Lautrup S, Sinclair DA, Mattson MP, Fang EF. NAD+ in brain aging and neurodegenerative disorders. Cell Metabolism. 2019.
- Mills KF, et al. Long‑term administration of nicotinamide mononucleotide mitigates age‑associated physiological decline in mice. Cell Metabolism. 2016.
- Fang EF, et al. NAD+ augmentation restores mitophagy and limits accelerated aging. Cell. 2019.
