Glutathione Detox IV Therapy | Lococo Wellness Clinic
Lococo Wellness Clinic • IV Therapy

Glutathione Detox IV Therapy

Glutathione is a naturally produced antioxidant that supports detoxification, redox balance, and cellular repair. Levels may decline with age, stress, diet, and environmental exposures. Glutathione IV therapy helps deliver glutathione directly into the bloodstream for immediate availability.

Book an Initial Consultation See Key Benefits

What is Glutathione?

Glutathione (GSH) is a tripeptide—glutamate, cysteine, and glycine—central to phase-II detoxification (conjugation), antioxidant recycling (vitamins C & E), and redox signaling. It helps neutralize reactive species and supports the body’s natural elimination processes.

💡 IV administration helps bypass digestion and first-pass metabolism, providing direct entry to the bloodstream.

Why Choose Glutathione IV Therapy?

Oral glutathione has variable absorption. An IV route supports immediate circulation and may offer higher near-term availability for targeted goals.

How a Session Works

Step 1: Assessment

🩺 Assessment & Candidacy Review
🙋‍♀️ You’ll do
  • Brief check-in (how you’re feeling today)
  • Vitals and comfort preferences (warm blanket, rate pacing)
  • Share goals for therapy (energy, skin tone, recovery, etc.)
🧑‍⚕️ We’ll do
  • Review recent labs to confirm candidacy
  • Safety screen, medications & supplements check
  • Personalize infusion rate and session plan
📄 Before we begin
If you are not currently a patient, an initial consultation is required.
If you are an existing patient, a follow-up consultation is needed to review your most recent blood work and confirm candidacy before beginning Glutathione IV therapy.
  • Helpful to have: recent labs (within ~6 weeks)
  • Bring a current meds/supplements list
  • Arrive hydrated or bring water

Step 2: IV Administration

Glutathione is infused slowly and comfortably, with real-time adjustments as needed.

Step 3: Post-Care

Hydration and simple after-care guidance. Most people resume normal activity the same day.

How Long is a Visit?

Most visits are approximately 1 hour. Timing can vary by individual factors.

How Often is it Used?

  • General wellness & redox support: about once every 1–2 weeks
  • Skin tone/brightness goals: 1–2× per week for a defined series, then taper
  • Higher exposures or complex needs: as recommended after assessment

Your plan depends on your goals, health status, and clinician guidance.

Glutathione IV vs Oral Supplements

Comparison of IV and oral glutathione features
Feature 💧 Glutathione IV Therapy 💊 Oral Glutathione
Delivery Direct bloodstream delivery (bypasses digestion) Subject to digestion and first-pass metabolism
Near-Term Availability Immediate entry to circulation Gradual availability with consistent use
Detox & Antioxidant Support May provide higher short-term antioxidant availability Supports ongoing maintenance over time
Often Chosen For Targeted goals, higher exposures, time-sensitive support Maintenance, general wellness routines

Ways Glutathione IV Therapy Supports You

🧹

Detox Support

🛡️

Immune Support

✨

Skin Brightness

⚡

Energy Support

🧬

Liver Support

🌿

Healthy Aging

🧠

Cognitive Clarity

Language is educational and non-guaranteeing. Experiences vary by individual.

Side Effects & Comfort

Glutathione IV is generally well-tolerated. A small number of people may notice brief, mild symptoms (for example, a headache or fatigue) as the body processes and eliminates compounds. Let your clinician know of any symptoms—slowing the rate or pausing briefly often helps.

Preparation & After-Care

  • Hydrate: Aim for 1–2 glasses of water beforehand.
  • Light snack: Helpful if you’re prone to lightheadedness.
  • Medication review: Bring your current list to the consultation.
  • After-care: Gentle movement and another glass of water post-visit.

Eligibility & Recent Lab Work

An initial consultation determines candidacy and individualizes care. We review recent blood work (typically within 6 weeks) before starting IV therapy.

View requested blood work
  • G6PD, CBC
  • Vitamin B12, Vitamin D, Ferritin, Iron Panel
  • Zinc, Calcium, Magnesium, Chloride, Potassium
  • Lipid Panel, Homocysteine
  • Amylase, Lipase, hs-CRP, Creatine Kinase
  • eGFR (kidney function)
  • TSH, Free T3, Free T4

You may ask your MD to requisition these labs. If not available, our clinic can requisition them at a cost paid by the patient.

Who may not be eligible?
  • Allergy or intolerance to any component
  • Unstable vitals or acute illness at the time of visit
  • Other findings during consultation indicating a different approach

Who Might Benefit from Glutathione IV Therapy?

  • Chronic fatigue or consistently low energy
  • Occasional brain fog, stress, or reduced focus
  • Higher exposure to toxins, pollution, or certain occupations
  • Goals for skin tone, brightness, and clarity
  • Liver support related to alcohol, medications, or processed foods
  • Athletes seeking recovery support and reduced inflammation
  • General immune and healthy-aging support

FAQs

Is IV glutathione “better” than oral?

Each route has considerations. IV delivery helps provide direct bloodstream availability for targeted goals, while oral strategies support ongoing maintenance. Your clinician will discuss options that fit your needs.

Can it be combined with other IVs?

Glutathione is sometimes paired with multi-nutrient IVs based on individualized plans. Combinations are discussed during consultation.

How will I feel during/after?

Most people are comfortable during the infusion. If you feel unwell at any point, we can slow or pause the infusion. Mild, short-lived effects can occur and typically resolve with simple measures.

References

  1. Pizzorno, J. (2014). Glutathione!. Integrative Medicine: A Clinician's Journal, 13(1), 8–12.
  2. Lu, S. C. (2013). Glutathione synthesis. BBA - General Subjects, 1830(5), 3143–3153. doi:10.1016/j.bbagen.2012.09.012
  3. Richie, J. P., Nichenametla, S., Neidig, W., et al. (2015). Randomized controlled trial of oral glutathione on body stores. Eur J Nutr, 54(2), 251–263. doi:10.1007/s00394-014-0706-z
  4. Droge, W., & Holm, E. (1997). Role of cysteine and glutathione in immune-related conditions. FASEB J, 11(13), 1077–1089. doi:10.1096/fasebj.11.13.9367456
  5. Handog, E. B., Datuin, M. S., & Singzon, I. A. (2016). Antioxidants in dermatology. J Clin Aesthet Dermatol, 9(9), 3–8.
  6. Weschawalit, S., Phutrakool, P., & Asawanonda, P. (2017). Glutathione & antimelanogenic effects. Clin Cosmet Investig Dermatol, 10, 147–153. doi:10.2147/CCID.S134619
  7. Zhang, H., & Forman, H. J. (2009). Glutathione synthesis & redox signaling in liver. Mol Aspects Med, 30(1–2), 42–59. doi:10.1016/j.mam.2008.06.001
  8. Pastore, A., Federici, G., Bertini, E., & Piemonte, F. (2003). Analysis of glutathione. Clin Chim Acta, 333(1), 19–39. doi:10.1016/S0009-8981(03)00200-6
  9. Lushchak, V. I. (2012). Glutathione homeostasis & functions. J Amino Acids, 2012, 736837. doi:10.1155/2012/736837
  10. Jones, D. P. (2008). Radical-free biology of oxidative stress. Am J Physiol Cell Physiol, 295(4), C849–C868. doi:10.1152/ajpcell.00283.2008
  11. Mischley, L. K., Vespignani, M. M., & Finnell, J. S. (2016). IV glutathione pharmacokinetics (Parkinson’s). PLOS ONE, 11(6), e0156753. doi:10.1371/journal.pone.0156753
  12. Bains, J. S., & Shaw, C. A. (1997). Glutathione in oxidative stress-mediated neuronal death. Brain Res Rev, 25(3), 335–358. doi:10.1016/S0165-0173(97)00045-3

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