Environmental Health Resource

Environmental Working Group:  http://www.ewg.org

Further Studies & Reports


Gonzalez, MJ, et.al.  Orthomolecular Oncology Review: Ascorbic Acid and Cancer 25 YearsLater.IntegrativeCancerTherapies4(1);200532-44DOI: 10.1177/1534735404273861


Ma, Y. et.al. (2011, November). Vitamin C and Lung Cancer: A Systematic Review. Moderated Abstract (49) presented at the Society for Integrative Oncology, Cleveland, OH.


Chen Q, et.al. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissuesProc Natl Acad Aci USA. 2005 Sep 20;102(38):13604-9. Epub 2005 Sep 12.


Chen Q, Espey, MG, and Aun AY, et al. Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo. Proc Natl Acad Sci USA. 2007; 104(21):8749-54. PMID: 17502596.


Chen P, Stone J, Sullivan G, Drisko JA, Chen Q.  Anti-cancer effect of pharmacologic ascorbate and its interaction with supplementary perenteral glutathione in preclinical cancer models. Free Radic Biol Med. 2011 May 30. PMID: 21672627


Sullivan, G. et.al. (2011, November).  Prospective Randomized phase1/lla Pilot Trial to Assess Safety and Benefit Administering High Dose Intravenous Ascorbate in Combination with Chemotherapy in Newly Diagnosed Advanced Stage 111 or Stage1V Ovarian Cancer. Moderated Abstract (6) presented at the Society for Integrative Oncology, Cleveland, OH.


Ma, Y. et. al. (2011 November).  Pharmacologic Ascorbate Synergizes with Gemcitabine in Pre-Clinical Models of Pancreatic Cancer.  Moderated Abstract (19) presented at the Society for Integrative Oncology, Cleveland, OH.


Volbracht C, et.al.  Intravenous vitamin C administration improves quality of life in breast cancer patients during chemo-/radiotherapy and aftercare: results of a retrospective, multicentre, epidemiological cohort study in Germany. In Vivo. 2011 Nov-Dec; 25(6) :983-90.


Heaney ML et al. Vitamin C Antagonizes the Cytotoxic Effects of Antineoplastic Drugs. Cancer Res 2008; 68:19:8031-8038.

Chiang CD et al. Ascorbic acid increases drug accumulation and reverses Vincristine resistance of human non-small-cell lung cancerBiochem J 1994; 301 (Pt 3): 759-64.


Song EJ et al. Potentiation of growth inhibition due to Vincristine by ascorbic acid in a resistant human non-small cell lung cancer cell lineEur J Pharmacol 1995; 292:2:119-25.

Kurbacher CM et al. Ascorbic acid (Vitamin C) improves the antineoplastic activity of doxorubicin, Cisplatinum, and pacltitaxel in human breast carcinoma cells in vitro. Cancer Letter 1996; 103:2:183-9.

Wells WW et al. Ascorbic acid and cell survival of Adriamycin resistant and sensitive MCF-7 breast tumor cellsFree Radic Biol Med 1995; 18:4:699-708.

Marian M et al. Potentiation of the biological activities of daunomycin and Adriamycin by ascorbic acid and dimethylsulfoxideExperientia 1982. 38:5:573-4.

Nagy B et al. Chemosensitizing effect of Vitamin C in combination with 5-fluorouracil in vitro. In Vivo 2003; 17:3:289-92.

Kammerer C et al. Enhancement of mitomycin C efficiency by Vitamin C, E-acetate and beta-carotene under irradiation. A study in vitro. Anticancer Res 1999; 19:6B:5319-21.

Abdel-Latiff MM et al. Vitamin C enhances chemosensitization of esophageal cancer cells in vitro. J Chemother 2005; 17:5:539-49.


Catani MV et al. Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damageBiochem J 2002; 364 (Pt 2): 441-7

Reddy VG et al. Vitamin C augments chemotherapeutic response of cervical carcinoma HeLa cells by stabilizing p53Biochem Biophys Res Commun 2001; 282:2:409-15.

Tarumoto T et al. Ascorbic acid restores sensitivity to imatinib via suppression of Nrf2-dependent gene expression in the imatinib-resistant cell lineExp Hematol 2004; 32:4:375-81.

Yam D et al. Suppression of tumor growth and metastasis by dietary fish oil combined with vitamins E and C and cisplatin. Cancer Chemother Pharmacol 2001; 47:1:34-40.

Kassouf W et al. Vitamins C and K3 sensitize human urothelial tumors to GemcitabineJ Urol 2006. 176 (4 Pt 1): 1642-7.

Taper HS et al. Non-toxic sensitization of cancer chemotherapy by combined Vitamin C and K3 pretreatment in a mouse tumor resistant to oncovinAnticancer Res. 1992; 5:1651-4.


Ma, Y. Drisko, J. Poilreddy, K. (2011 November).  Synergistic Effects of Ascorbate with Carboplatin against Human Ovarian Cancer in Vitro and in Vivo. Moderated Abstract (20) presented at the Society for Integrative Oncology, Cleveland, OH.


Fromberg, A, et.al.  Ascorbate Exerts anti-proliferative effects through cell cycle inhibition and sensitizes tumor cells towards cytostatic drugs. Cancer Chemother Pharmacol,  67:1157-1166, 2011. DOI 10.1007/s00280-010-1418-6 (Springer online).


Monti DA, et.al. Phase 1 evaluation intravenous ascorbic Acid in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer.  PLoS One.  2012;7(1):e29794. Epub 2012 Jan 17.